About MTA

MISSION

To improve the outcomes of kidney and pancreas transplant recipients through innovative and efficient clinical trials conducted by leading medical institutions around the world.

FACTS

Multicenter Transplant Alliance is a research consortium focusing on kidney (MTA-K) and pancreas (MTA-P) transplantation outcomes.
MTA is comprised of 13 leading medical institutions in the United States.
The coordinating center for Multicenter Transplant Alliance is at Mayo Clinic, Rochester, MN.
MTA is the only freestanding clinical trials consortium in transplantation.
MTA-k programs collectively transplant more than 1,500 people each year - 10% of the total number of kidney transplants in the US.
MTA-p programs collectively performs 20% of all pancreas transplants in the US each year.

ABOUT

The inability to perform clinical trials that can be appropriately powered and enrolled in a reasonable time have been major barriers to developing new therapy. In addition, single-center practices and experience can vary widely leading to erroneous assumptions about expected outcomes and appropriate endpoints. To address these issues and to better perform an Adaptive Clinical Trial study, we established the Multicenter Transplant Alliance—Kidney (MTA-K) and -Pancreas (MTA-P) in 2015. Our group aims to improve long-term outcomes of kidney and pancreas transplant recipients.

The MTA is ideally suited to Adaptive Trial Design (ATD) clinical trials. Patient care protocols are standardized across the consortium. Collectively, the MTA-K performs approximately 1300 solitary kidney transplants each year which is 10% of all the kidney transplants in the US, while MTA-P performs approximately 20% of all pancreas transplants in the US. This ensures sufficient numbers of patients with specific phenotypes to do clinical trials. Patients in the MTA clinical trials are diverse and represent the entire spectrum of the US transplant population: 65 % are recipients of deceased donors and 40% are Hispanic or African American.

The MTA has a clearly-defined organizational structure with signed membership agreements approved by the legal departments of the various institutions. It is based on similar research consortia in oncology and HIV areas. The Coordinating Center is at Mayo Clinic, Rochester, MN and the Director is Dr. Mark D. Stegall, a transplant surgeon and researcher. Each site has a voting member on the Steering Committee. Members agree to share data via a common database (Medidata Rave) and research coordinators exist at each site with time devoted to the MTA activities

2015

MTA Founded at Mayo Clinic - Rochester, MN

2016

Design of Adaptive Clinical Trials & Launch of MTA Brand

2017

First year of Clinical Trial Operations

TEAM

MTA-Pancreas

Yogish Kudva, M.B.B.S
Mayo Clinic - Rochester
Kunam Reddy, M.B.B.S
Mayo Clinic - Arizona
Jon Odorico, M.D.
University of Wisconsin
Jonathan Fridell, M.D.
Indiana University
George Burke, M.D.
University of Miami
Peter Stock, M.D.
University of California, San Francisco
Robert Stratta, M.D.
Wake Forest University
Matthew Everly, PharmD, BCPS, FAST
Terasaki Research Institute – Los Angeles, CA
Raja Kandaswamy, M.D.
University of Minnesota

MTA-Kidney

Mark Stegall, M.D.
Mayo Clinic - Rochester, MN
Mollie Luhman
Mayo Clinic - Rochester, MN
Carrie Schinstock, M.D
Mayo Clinic - Rochester, MN
Patrick Dean, M.D.
Mayo Clinic - Rochester, MN
Elizabeth C. Lorenz, M.D.
Mayo Clinic - Rochester, MN
Yogish Kudva, M.B.B.S
Mayo Clinic - Rochester, MN
Hatem Amer, M.D.
Mayo Clinic - Rochester, MN
Aleksandra Kukla, M.D.
Mayo Clinic - Rochester, MN
Byron Smith, Ph.D.
Mayo Clinic - Rochester, MN
Walter Park
Mayo Clinic - Rochester, MN
Nong Braaten
Mayo Clinic - Rochester, MN
Leah M. Majerus
Mayo Clinic - Rochester, MN
Raymond Heilman, M.D.
Mayo Clinic - Scottsdale, AZ
Chakkera Harini, M.D.
Mayo Clinic - Scottsdale, AZ
Kunam Reddy, M.B.B.S
Mayo Clinic - Scottsdale, AZ
Martin Mai, M.D.
Mayo Clinic – Jacksonville, FL
Dana Perry, M.D.
Mayo Clinic – Jacksonville, FL
Milagros (Millie) Samaniego-Picota, M.D.
University of Michigan – Ann Arbor, MI
Sundaram Hariharan, M.D.
University of Pittsburg, Pittsburg, PA
Matthew Everly, PharmD, BCPS, FAST
Terasaki Research Insitute – Los Angeles, CA
Darshana M. Dadhani, M.D.
Cornell University – New York, NY
Dean Kim, M.D.
Henry Ford Hospital – Detroit, MI
Collen Jay, M.D.
Wake Forest – Winston Salem, NC
Fadi G Lakkis, M.D.
University of Pittsburg – Pittsburg, PA
David Leeser, M.D.
East Carolina University – Greenville, NC
Samantha Parker
Mayo Clinic – Scottsdale, AZ
Joel Espinoza
Mayo Clinic – Jacksonville, FL